| Study, Year | Total Patients (N) | PCT Arm | Control Arm | *p-value (Tx duration) | Outcomes | ||||
| Patients (N) | Tx duration (d) | Mortality†, N (%) | Patients (N) | Tx duration (d) | Mortality†, N (%) | ||||
| Nobre, 2007 [25] | 68 | 31 | 6 (95% CI, 4 - 16) d | 5 (16%) | 37 | 10 (95% CI, 3 - 33) d | 6 (16%) | p = 0.003 | ABx duration decreased by 4 d in PCT arm |
| Hochreiter, 2009 [26] | 110 | 57 | 5.9 ± 1.7 d | 15 (26%) | 53 | 7.9 ± 0.5 d | 14 (26%) | p < 0.001 | ABx duration decreased by 2 d in PCT arm |
| Schroeder, 2009 [27] | 27 | 14 | 6.6 ± 1.1 d | 3 (21%) | 13 | 8.3 ± 0.7 d | 3 (23%) | p < 0.001 | ABx duration decreased by 1.7 d in PCT arm |
| Bouadma, 2010 [28] | 621 | 307 | 14.3 ± 9.1 d w/o ABx | 65 (21%) | 314 | 11.6 ± 8.2 d w/o ABx | 64 (20%) | p < 0.0001 | ABx duration decreased by 2.7 d in PCT arm |